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The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR(clusteredregularly,interspaced,short,palindromic,repeats),bacterial,immune,systems,is,becoming anessential tool for engineering the genome in diverse organisms. As anRNAguidedDNAendonuclease,Cas9,is,designatedtotarget,new,sites,by,altering,its,guide,RNA,sequence,and,its,development,as,a,tool,has,madesequencespecific,gene,editing,much,easier.The,nucleasedeactivated,form,of,dCas9,further,provides,a,versatile,RNA,guided,DNAtargeting,platform,for regulating and imaging the genome in nucleus, as well as for rewriting the epigenetic dynamics, all in a sequence-specific manner. With all of these progress, scientists have begun to explore the possible applications of Cas9 in biomedical research and therapeutics. Novatein Biosciences is working hard to help you in fully utilize the Cas9 related proteins, antibodies, and assay kit to advance your projects. We focus on the applications of Cas9 proteins for genome editing, regulation, and subcellular localization of target genes.
Cas9蛋白(CRISPR相關(guān)蛋白9)來(lái)源于II型CRISPR(聚集的規(guī)則間隔的短回文重復(fù)序列)細(xì)菌免疫系統(tǒng),正成為在多種生物中構(gòu)建基因組的重要工具。Cas9作為一種RNA引導(dǎo)的DNA內(nèi)切酶,通過(guò)改變其引導(dǎo)RNA序列來(lái)定位新的位點(diǎn),其作為一種工具的發(fā)展使序列特異性基因編輯變得更加容易。核酸酶失活形式的dCas9進(jìn)一步提供了一個(gè)多功能的RNA引導(dǎo)的DNA靶向平臺(tái),用于調(diào)控和成像細(xì)胞核中的基因組,以及重寫表觀遺傳動(dòng)力學(xué),所有這些都是以序列特異的方式進(jìn)行的。隨著這些進(jìn)展,科學(xué)家們開(kāi)始探索Cas9在生物醫(yī)學(xué)研究和治療學(xué)中的可能應(yīng)用。Novatein Biosciences正在努力幫助您充分利用Cas9相關(guān)的蛋白質(zhì)、抗體和檢測(cè)試劑盒來(lái)推進(jìn)您的項(xiàng)目。我們重點(diǎn)研究Cas9蛋白在基因組編輯、調(diào)控和靶基因亞細(xì)胞定位中的應(yīng)用。
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